GlutaredoxinV1, Main, Exploration, bibRecord, 000136

Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function.

Identifieur interne : 000136 ( Main/Exploration ); précédent : 000135; suivant : 000137

Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function.

Auteurs : Camille Tremblay-Laganière [Canada] ; Léa Garneau [Canada] ; Jean-François Mauger [Canada] ; Vian Peshdary [Canada] ; Ella Atlas [Canada] ; Alyssa Samantha Nikolla [Canada] ; Natalie Ann Chapados [Canada] ; Céline Aguer [Canada]

Source :

Environmental science and pollution research international [ 1614-7499 ] ; 2019.

RBID : pubmed:30467749

Descripteurs français

English descriptors

KwdEn :
- Animals (MeSH), Catalase (genetics), Catalase (metabolism), Cytochrome P-450 CYP1A1 (genetics), Cytochrome P-450 CYP1A1 (metabolism), Environmental Pollutants (toxicity), Female (MeSH), Gene Expression Regulation, Enzymologic (drug effects), Glutaredoxins (genetics), Glutaredoxins (metabolism), Inactivation, Metabolic (drug effects), Inactivation, Metabolic (genetics), Mitochondria, Muscle (drug effects), Mitochondria, Muscle (metabolism), Muscle Fibers, Skeletal (drug effects), Muscle Fibers, Skeletal (metabolism), Muscle, Skeletal (drug effects), Muscle, Skeletal (metabolism), Oxidative Stress (drug effects), Oxygen (metabolism), Polychlorinated Biphenyls (toxicity), Rats, Sprague-Dawley (MeSH).
MESH :
- chemical , genetics : Catalase, Cytochrome P-450 CYP1A1, Glutaredoxins.
- chemical , metabolism : Catalase, Cytochrome P-450 CYP1A1, Glutaredoxins, Oxygen.
- chemical , toxicity : Environmental Pollutants, Polychlorinated Biphenyls.
- drug effects : Gene Expression Regulation, Enzymologic, Inactivation, Metabolic, Mitochondria, Muscle, Muscle Fibers, Skeletal, Muscle, Skeletal, Oxidative Stress.
- genetics : Inactivation, Metabolic.
- metabolism : Mitochondria, Muscle, Muscle Fibers, Skeletal, Muscle, Skeletal.
- Animals, Female, Rats, Sprague-Dawley.

Abstract

In the past few years, polychlorinated biphenyls (PCBs), a class of environmental pollutants, have been associated with metabolism dysregulation. Muscle is one of the key regulators of metabolism because of its mass and its important role in terms of glucose consumption and glucose storage. It has been shown that muscle alterations, such as oxidative stress and mitochondrial dysfunction, contribute significantly to the development of metabolic diseases. No study has yet investigated the toxicological effect of PCBs on muscle mitochondrial function and oxidative stress in vivo. The aim of this study was to assess the effect of PCB126 in vivo exposure (single dose of 1.05 μmol/kg) on muscle mitochondrial function and oxidative stress in rats. PCB126-treated rats showed a marked increase in Cyp1a1 mRNA levels in skeletal muscles in association with a 40% reduction in state 3 oxygen consumption rate measured with complex I substrates in permeabilized muscle fibers. Furthermore, PCB126 exposure altered the expression of some enzymes involved in ROS detoxification such as catalase and glutaredoxin 2. Our results highlight for the first time a toxic effect of coplanar PCBs on skeletal muscle mitochondrial function and oxidative stress. This suggests that acute PCB exposure, by affecting muscle metabolism, could contribute to the development of metabolic disorders. Studies are needed to determine if lower-level but longer-term PCB exposure exhibits the same effect.

DOI: 10.1007/s11356-018-3738-8
PubMed: 30467749

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000192
to stream Main, to step Curation: 000192

Le document en format XML

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<author><name sortKey="Chapados, Natalie Ann" sort="Chapados, Natalie Ann" uniqKey="Chapados N" first="Natalie Ann" last="Chapados">Natalie Ann Chapados</name>
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<author><name sortKey="Aguer, Celine" sort="Aguer, Celine" uniqKey="Aguer C" first="Céline" last="Aguer">Céline Aguer</name>
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<term>Catalase (genetics)</term>
<term>Catalase (metabolism)</term>
<term>Cytochrome P-450 CYP1A1 (genetics)</term>
<term>Cytochrome P-450 CYP1A1 (metabolism)</term>
<term>Environmental Pollutants (toxicity)</term>
<term>Female (MeSH)</term>
<term>Gene Expression Regulation, Enzymologic (drug effects)</term>
<term>Glutaredoxins (genetics)</term>
<term>Glutaredoxins (metabolism)</term>
<term>Inactivation, Metabolic (drug effects)</term>
<term>Inactivation, Metabolic (genetics)</term>
<term>Mitochondria, Muscle (drug effects)</term>
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<term>Muscle Fibers, Skeletal (drug effects)</term>
<term>Muscle Fibers, Skeletal (metabolism)</term>
<term>Muscle, Skeletal (drug effects)</term>
<term>Muscle, Skeletal (metabolism)</term>
<term>Oxidative Stress (drug effects)</term>
<term>Oxygen (metabolism)</term>
<term>Polychlorinated Biphenyls (toxicity)</term>
<term>Rats, Sprague-Dawley (MeSH)</term>
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<term>Catalase (génétique)</term>
<term>Catalase (métabolisme)</term>
<term>Cytochrome P-450 CYP1A1 (génétique)</term>
<term>Cytochrome P-450 CYP1A1 (métabolisme)</term>
<term>Femelle (MeSH)</term>
<term>Fibres musculaires squelettiques (effets des médicaments et des substances chimiques)</term>
<term>Fibres musculaires squelettiques (métabolisme)</term>
<term>Glutarédoxines (génétique)</term>
<term>Glutarédoxines (métabolisme)</term>
<term>Inactivation métabolique (effets des médicaments et des substances chimiques)</term>
<term>Inactivation métabolique (génétique)</term>
<term>Mitochondries du muscle (effets des médicaments et des substances chimiques)</term>
<term>Mitochondries du muscle (métabolisme)</term>
<term>Muscles squelettiques (effets des médicaments et des substances chimiques)</term>
<term>Muscles squelettiques (métabolisme)</term>
<term>Oxygène (métabolisme)</term>
<term>Polluants environnementaux (toxicité)</term>
<term>Polychlorobiphényles (toxicité)</term>
<term>Rat Sprague-Dawley (MeSH)</term>
<term>Régulation de l'expression des gènes codant pour des enzymes (effets des médicaments et des substances chimiques)</term>
<term>Stress oxydatif (effets des médicaments et des substances chimiques)</term>
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<term>Cytochrome P-450 CYP1A1</term>
<term>Glutaredoxins</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catalase</term>
<term>Cytochrome P-450 CYP1A1</term>
<term>Glutaredoxins</term>
<term>Oxygen</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Environmental Pollutants</term>
<term>Polychlorinated Biphenyls</term>
</keywords>
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<term>Inactivation, Metabolic</term>
<term>Mitochondria, Muscle</term>
<term>Muscle Fibers, Skeletal</term>
<term>Muscle, Skeletal</term>
<term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Fibres musculaires squelettiques</term>
<term>Inactivation métabolique</term>
<term>Mitochondries du muscle</term>
<term>Muscles squelettiques</term>
<term>Régulation de l'expression des gènes codant pour des enzymes</term>
<term>Stress oxydatif</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Inactivation, Metabolic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Catalase</term>
<term>Cytochrome P-450 CYP1A1</term>
<term>Glutarédoxines</term>
<term>Inactivation métabolique</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mitochondria, Muscle</term>
<term>Muscle Fibers, Skeletal</term>
<term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Catalase</term>
<term>Cytochrome P-450 CYP1A1</term>
<term>Fibres musculaires squelettiques</term>
<term>Glutarédoxines</term>
<term>Mitochondries du muscle</term>
<term>Muscles squelettiques</term>
<term>Oxygène</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Polluants environnementaux</term>
<term>Polychlorobiphényles</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Rats, Sprague-Dawley</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Rat Sprague-Dawley</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">In the past few years, polychlorinated biphenyls (PCBs), a class of environmental pollutants, have been associated with metabolism dysregulation. Muscle is one of the key regulators of metabolism because of its mass and its important role in terms of glucose consumption and glucose storage. It has been shown that muscle alterations, such as oxidative stress and mitochondrial dysfunction, contribute significantly to the development of metabolic diseases. No study has yet investigated the toxicological effect of PCBs on muscle mitochondrial function and oxidative stress in vivo. The aim of this study was to assess the effect of PCB126 in vivo exposure (single dose of 1.05 μmol/kg) on muscle mitochondrial function and oxidative stress in rats. PCB126-treated rats showed a marked increase in Cyp1a1 mRNA levels in skeletal muscles in association with a 40% reduction in state 3 oxygen consumption rate measured with complex I substrates in permeabilized muscle fibers. Furthermore, PCB126 exposure altered the expression of some enzymes involved in ROS detoxification such as catalase and glutaredoxin 2. Our results highlight for the first time a toxic effect of coplanar PCBs on skeletal muscle mitochondrial function and oxidative stress. This suggests that acute PCB exposure, by affecting muscle metabolism, could contribute to the development of metabolic disorders. Studies are needed to determine if lower-level but longer-term PCB exposure exhibits the same effect.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30467749</PMID>
<DateCompleted><Year>2019</Year>
<Month>03</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1614-7499</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>26</Volume>
<Issue>3</Issue>
<PubDate><Year>2019</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>Environmental science and pollution research international</Title>
<ISOAbbreviation>Environ Sci Pollut Res Int</ISOAbbreviation>
</Journal>
<ArticleTitle>Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function.</ArticleTitle>
<Pagination><MedlinePgn>2375-2386</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s11356-018-3738-8</ELocationID>
<Abstract><AbstractText>In the past few years, polychlorinated biphenyls (PCBs), a class of environmental pollutants, have been associated with metabolism dysregulation. Muscle is one of the key regulators of metabolism because of its mass and its important role in terms of glucose consumption and glucose storage. It has been shown that muscle alterations, such as oxidative stress and mitochondrial dysfunction, contribute significantly to the development of metabolic diseases. No study has yet investigated the toxicological effect of PCBs on muscle mitochondrial function and oxidative stress in vivo. The aim of this study was to assess the effect of PCB126 in vivo exposure (single dose of 1.05 μmol/kg) on muscle mitochondrial function and oxidative stress in rats. PCB126-treated rats showed a marked increase in Cyp1a1 mRNA levels in skeletal muscles in association with a 40% reduction in state 3 oxygen consumption rate measured with complex I substrates in permeabilized muscle fibers. Furthermore, PCB126 exposure altered the expression of some enzymes involved in ROS detoxification such as catalase and glutaredoxin 2. Our results highlight for the first time a toxic effect of coplanar PCBs on skeletal muscle mitochondrial function and oxidative stress. This suggests that acute PCB exposure, by affecting muscle metabolism, could contribute to the development of metabolic disorders. Studies are needed to determine if lower-level but longer-term PCB exposure exhibits the same effect.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tremblay-Laganière</LastName>
<ForeName>Camille</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Garneau</LastName>
<ForeName>Léa</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Medicine, Biochemistry, Microbiology and Immunology Department, University of Ottawa, Ottawa, ON, K1H 8L1, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mauger</LastName>
<ForeName>Jean-François</ForeName>
<Initials>JF</Initials>
<AffiliationInfo><Affiliation>Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Peshdary</LastName>
<ForeName>Vian</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Faculty of Medicine, Biochemistry, Microbiology and Immunology Department, University of Ottawa, Ottawa, ON, K1H 8L1, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Atlas</LastName>
<ForeName>Ella</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Faculty of Medicine, Biochemistry, Microbiology and Immunology Department, University of Ottawa, Ottawa, ON, K1H 8L1, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nikolla</LastName>
<ForeName>Alyssa Samantha</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chapados</LastName>
<ForeName>Natalie Ann</ForeName>
<Initials>NA</Initials>
<AffiliationInfo><Affiliation>Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Health Sciences, School of Human Kinetics, University of Ottawa, Ottawa, ON, K1S 5N5, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aguer</LastName>
<ForeName>Céline</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-8828-8472</Identifier>
<AffiliationInfo><Affiliation>Institut du Savoir Montfort - Recherche, 713 Montreal Rd, Ottawa, ON, K1K 0T2, Canada. celineaguer@montfort.on.ca.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Medicine, Biochemistry, Microbiology and Immunology Department, University of Ottawa, Ottawa, ON, K1H 8L1, Canada. celineaguer@montfort.on.ca.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>(N/A)</GrantID>
<Agency>Institut du Savoir Montfort - Recherche</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>2015-06263</GrantID>
<Agency>Natural Sciences and Engineering Research Council of Canada</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>418312-2012</GrantID>
<Agency>Natural Sciences and Engineering Research Council of Canada</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>Undergraduate Research Opportunity Program scholarship</GrantID>
<Agency>University of Ottawa</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>Chemical Management Plan</GrantID>
<Agency>Health Canada</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>11</Month>
<Day>22</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Environ Sci Pollut Res Int</MedlineTA>
<NlmUniqueID>9441769</NlmUniqueID>
<ISSNLinking>0944-1344</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004785">Environmental Pollutants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>DFC2HB4I0K</RegistryNumber>
<NameOfSubstance UI="D011078">Polychlorinated Biphenyls</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.6</RegistryNumber>
<NameOfSubstance UI="D002374">Catalase</NameOfSubstance>
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<Chemical><RegistryNumber>EC 1.14.14.1</RegistryNumber>
<NameOfSubstance UI="D019363">Cytochrome P-450 CYP1A1</NameOfSubstance>
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<Chemical><RegistryNumber>S88TT14065</RegistryNumber>
<NameOfSubstance UI="D010100">Oxygen</NameOfSubstance>
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<Chemical><RegistryNumber>TSH69IA9XF</RegistryNumber>
<NameOfSubstance UI="C023035">3,4,5,3',4'-pentachlorobiphenyl</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002374" MajorTopicYN="N">Catalase</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019363" MajorTopicYN="N">Cytochrome P-450 CYP1A1</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D004785" MajorTopicYN="N">Environmental Pollutants</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015971" MajorTopicYN="N">Gene Expression Regulation, Enzymologic</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
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<MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D008658" MajorTopicYN="N">Inactivation, Metabolic</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008931" MajorTopicYN="N">Mitochondria, Muscle</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018485" MajorTopicYN="N">Muscle Fibers, Skeletal</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018482" MajorTopicYN="N">Muscle, Skeletal</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010100" MajorTopicYN="N">Oxygen</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011078" MajorTopicYN="N">Polychlorinated Biphenyls</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Electron transport chain</Keyword>
<Keyword MajorTopicYN="N">Oxidative phosphorylation</Keyword>
<Keyword MajorTopicYN="N">Oxidative stress</Keyword>
<Keyword MajorTopicYN="N">Polychlorinated biphenyls</Keyword>
<Keyword MajorTopicYN="N">Skeletal muscle metabolism</Keyword>
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<Day>12</Day>
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<affiliations><list><country><li>Canada</li>
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<name sortKey="Garneau, Lea" sort="Garneau, Lea" uniqKey="Garneau L" first="Léa" last="Garneau">Léa Garneau</name>
<name sortKey="Garneau, Lea" sort="Garneau, Lea" uniqKey="Garneau L" first="Léa" last="Garneau">Léa Garneau</name>
<name sortKey="Mauger, Jean Francois" sort="Mauger, Jean Francois" uniqKey="Mauger J" first="Jean-François" last="Mauger">Jean-François Mauger</name>
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<name sortKey="Peshdary, Vian" sort="Peshdary, Vian" uniqKey="Peshdary V" first="Vian" last="Peshdary">Vian Peshdary</name>
<name sortKey="Tremblay Laganiere, Camille" sort="Tremblay Laganiere, Camille" uniqKey="Tremblay Laganiere C" first="Camille" last="Tremblay-Laganière">Camille Tremblay-Laganière</name>
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{{Explor lien
   |wiki=    Bois
   |area=    GlutaredoxinV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30467749
   |texte=   Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function.
}}

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       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
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	Serveur d'exploration sur la glutarédoxine
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Serveur d'exploration sur la glutarédoxine

Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function.

Polychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function.

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